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Title:

Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen.

Document type:
Journal Article
Author(s):
Kruetzmann, S; Rosado, MM; Weber, H; Germing, U; Tournilhac, O; Peter, HH; Berner, R; Peters, A; Boehm, T; Plebani, A; Quinti, I; Carsetti, R
Abstract:
Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bac...     »
Journal title abbreviation:
J Exp Med
Year:
2003
Journal volume:
197
Journal issue:
7
Pages contribution:
939-45
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20022020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12682112
Print-ISSN:
0022-1007
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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