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Title:

Targeting cancer cells: magnetic nanoparticles as drug carriers.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Alexiou, C; Schmid, RJ; Jurgons, R; Kremer, M; Wanner, G; Bergemann, C; Huenges, E; Nawroth, T; Arnold, W; Parak, FG
Abstract:
Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cel...     »
Journal title abbreviation:
Eur Biophys J
Year:
2006
Journal volume:
35
Journal issue:
5
Pages contribution:
446-50
Language:
eng
Fulltext / DOI:
doi:10.1007/s00249-006-0042-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16447039
Print-ISSN:
0175-7571
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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