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Title:

Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: an experimental study in guinea pigs.

Document type:
Journal Article; Article
Author(s):
Arnold, W; Senn, P; Hennig, M; Michaelis, C; Deingruber, K; Scheler, R; Steinhoff, HJ; Riphagen, F; Lamm, K
Abstract:
Novel drug release microimplants (0.8 x 1.14 mm; custom-made by Leiras, now Schering OY, Finland) of slow- and fast-release types containing either 0.9 mg beclomethasone or no drug at all were placed unilaterally onto the round-window membrane (RWM) of 45 guinea pigs for a maximum duration of 28 days. The following parameters were tested on days 1, 14 and 28 after implantation: threshold levels of beclomethasone in the perilymph of the scala tympani, auditory brain stem responses (ABR threshold...     »
Journal title abbreviation:
Audiol Neurootol
Year:
2005
Journal volume:
10
Journal issue:
1
Pages contribution:
53-63
Language:
eng
Fulltext / DOI:
doi:10.1159/000082575
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15591792
Print-ISSN:
1420-3030
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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