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Title:

Neither moxifloxacin nor cefuroxime produces significant attenuation of inflammatory mediator release in patients exposed to cardiopulmonary bypass: a randomized controlled trial.

Document type:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Author(s):
Wiesner, G; Braun, SL; Gruber, M; Gertler, R; Lange, R; Tassani, P; Martin, K
Abstract:
In vitro and experimental studies in animals have established the anti-inflammatory effects of moxifloxacin. Cardiopulmonary bypass (CPB) leads to an inflammatory response. The aim of this study was to assess whether the inflammatory cytokine response to CPB is reduced with a perioperative antibiotic prophylaxis, either moxifloxacin or cefuroxime (the standard prophylaxis).Twenty-eight patients scheduled for elective coronary artery bypass grafting with CPB were randomly assigned to receive eith...     »
Journal title abbreviation:
J Antimicrob Chemother
Year:
2012
Journal volume:
67
Journal issue:
1
Pages contribution:
230-3
Language:
eng
Fulltext / DOI:
doi:10.1093/jac/dkr397
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21972268
Print-ISSN:
0305-7453
TUM Institution:
Fachgebiet Kardioanästhesie (Prof. Tassani-Prell); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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