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Titel:

EMMPRIN (CD 147) is a central activator of extracellular matrix degradation by Chlamydia pneumoniae-infected monocytes. Implications for plaque rupture.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schmidt, R; Redecke, V; Breitfeld, Y; Wantia, N; Miethke, T; Massberg, S; Fischel, S; Neumann, FJ; Schömig, A; May, AE
Abstract:
Chlamydia (C.) pneumoniae are thought to infect monocytes and use them as vectors into the vessel wall, where they may accelerate atherosclerosis. We investigated the effects of C. pneumoniae on monocytic matrix metalloproteinase (MMP) activation with focus on the role of the extracellular matrix metalloproteinase inducer EMMPRIN. Human monocytes or monocytic MonoMac6 cells were infected with C. pneumoniae. Infection enhanced mRNA- and surface expression of EMMPRIN and Membrane-type-1 Matrix Met...     »
Zeitschriftentitel:
Thromb Haemost
Jahr:
2006
Band / Volume:
95
Heft / Issue:
1
Seitenangaben Beitrag:
151-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16543974
Print-ISSN:
0340-6245
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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