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Title:

Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway.

Document type:
Journal Article
Author(s):
Qing, M; Nimmesgern, A; Heinrich, PC; Schumacher, K; Vazquez-Jimenez, JF; Hess, J; von Bernuth, G; Seghaye, MC
Abstract:
SUMMARY: OBJECTIVES To identify the signaling pathways involved in the anti-inflammatory shift of the cytokine balance due to hypothermia during cardiopulmonary bypass.DESIGN Experimental animal study.SETTING Department of experimental surgery of a university hospital.SUBJECTS Young pigs.INTERVENTIONS Animals underwent normothermic (37 degrees C) or hypothermic (28 degrees C) cardiopulmonary bypass (n = 6 each). Samples of liver tissue were taken before and 6 hrs after cardiopulmonary bypass.MEA...     »
Journal title abbreviation:
Crit Care Med
Year:
2003
Journal volume:
31
Journal issue:
12
Pages contribution:
2769-75
Language:
eng
Fulltext / DOI:
doi:10.1097/01.CCM.0000098858.64868.9C
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14668613
Print-ISSN:
0090-3493
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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