Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schonberger, T; Ziegler, M; Borst, O; Konrad, I; Nieswandt, B; Massberg, S; Ochmann, C; Jürgens, T; Seizer, P; Langer, H; Munch, G; Ungerer, M; Preissner, KT; Elvers, M; Gawaz, M
Abstract:
Platelets play a critical role in the pathophysiology of reperfusion, sepsis, and cardiovascular diseases. In a multiple step process, they adhere to activated endothelium and release proinflammatory cytokines thereby promoting the inflammatory process. Glycoprotein VI (GPVI) is the major collagen receptor on the platelet surface and triggers platelet activation and primary hemostasis. Activation of GPVI leads to stable platelet adhesion and degranulation of platelet granules. However, GPVI is c...     »
Zeitschriftentitel:
Am J Physiol Cell Physiol
Jahr:
2012
Band / Volume:
303
Heft / Issue:
7
Seitenangaben Beitrag:
C757-66
Sprache:
eng
Volltext / DOI:
doi:10.1152/ajpcell.00060.2012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22814400
Print-ISSN:
0363-6143
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
 BibTeX