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Title:

Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Freynhagen, R; Vogt, J; Lipfert, P; Muth-Selbach, U
Abstract:
The antidepressant mirtazapine is an optically active drug and currently marketed as a racemic compound consisting of its S(+) and R(-)-enantiomers in a 50:50 mixture. As stereochemistry of antidepressants has become increasingly important to consider for the relevance of their analgesic properties, we investigated the effect of (+/-)-mirtazapine and its enantiomers in an animal model of acute thermal nociception. Wistar rats were injected intrathecal with either (+/-)-mirtazapine, R(-)-mirtazap...     »
Journal title abbreviation:
Brain Res Bull
Year:
2006
Journal volume:
69
Journal issue:
2
Pages contribution:
168-73
Language:
eng
Fulltext / DOI:
doi:10.1016/j.brainresbull.2005.11.017
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16533666
Print-ISSN:
0361-9230
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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