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Title:

Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520.

Document type:
Journal Article
Author(s):
Bieler, A; Mantwill, K; Dravits, T; Bernshausen, A; Glockzin, G; Köhler-Vargas, N; Lage, H; Gansbacher, B; Holm, PS
Abstract:
Resistance to radiation and chemotherapy remains an obstacle to the treatment of brain tumors. We have demonstrated that the replication-deficient adenovirus d1520, which lacks the E1A 13S protein, replicates efficiently and exhibits oncolytic potential in multidrug-resistant cells with nuclear localization of the human transcription factor YB-1. However, besides others, key factors regarding oncolytic virotherapy are limited tumor transduction rate and low replication efficiency. The objective...     »
Journal title abbreviation:
Hum Gene Ther
Year:
2006
Journal volume:
17
Journal issue:
1
Pages contribution:
55-70
Language:
eng
Fulltext / DOI:
doi:10.1089/hum.2006.17.55
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16409125
Print-ISSN:
1043-0342
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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