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Titel:

Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment.

Dokumenttyp:
Journal Article; Article
Autor(en):
Arlt, MJ; Novak-Hofer, I; Gast, D; Gschwend, V; Moldenhauer, G; Grünberg, J; Honer, M; Schubiger, PA; Altevogt, P; Kruger, A
Abstract:
The L1 cell adhesion molecule is implicated in the control of proliferation, migration, and invasion of several tumor cell types in vitro. Recently, L1 overexpression was found to correlate with tumor progression of ovarian carcinoma, one of the most common causes of cancer-related deaths in gynecologic malignant diseases. To evaluate L1 as a potential target for ovarian cancer therapy, we investigated the effects of anti-L1 monoclonal antibodies (chCE7 and L1-11A) on proliferation and migration...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2006
Band / Volume:
66
Heft / Issue:
2
Seitenangaben Beitrag:
936-43
Sprache:
eng
Volltext / DOI:
doi:10.1158/0008-5472.CAN-05-1818
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16424028
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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