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Title:

New HIV-drug inhibits in vitro bladder cancer migration and invasion.

Document type:
Journal Article; Article
Author(s):
Retz, M; Sidhu, SS; Lehmann, J; Tamamura, H; Fujii, N; Basbaum, C
Abstract:
OBJECTIVE: The CXCR4/CXCL12 axis appears crucial in the metastasis of bladder cancer. Our aim was to evaluate the potency of the CXCR4 antagonist, 4F-benzoyl-TE14011 (4F-bTE), as an anti-metastatic drug in this disease. In this study, we assessed the ability of 4F-bTE to inhibit tumor cell motility, invasion through extracellular matrix (ECM), matrix metalloproteinase (MMP) secretion and cytoskeletal responses to chemokine. METHODS: To assess the degree to which cells could migrate and invade EC...     »
Journal title abbreviation:
Eur Urol
Year:
2005
Journal volume:
48
Journal issue:
6
Pages contribution:
1025-30
Language:
eng
Fulltext / DOI:
doi:10.1016/j.eururo.2005.07.016
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16140456
Print-ISSN:
0302-2838
TUM Institution:
Urologische Klinik und Poliklinik
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