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Title:

[Ex-vivo gene therapy with BMP-4 for critically sized defects and enhancement of fracture healing in an osteoporotic animal model]

Document type:
Journal Article; Article
Author(s):
Rose, T; Peng, H; Usas, A; Josten, C; Fu, FH; Huard, J
Abstract:
Fractures in osteoporotic bones or segment defects are problematic bone lesions with a reduced biological capability of regeneration. We tested the hypothesis that cell-mediated ex vivo gene therapy to deliver BMP4 can heal critically sized defects and improve bone healing in osteoporotic rats. Primary muscle-derived cells were isolated from the hindlimb muscle of rats and retrovirally transduced to express bone morphogenic protein 4 (BMP4). The bone formation was evaluated following local appli...     »
Journal title abbreviation:
Unfallchirurg
Year:
2005
Journal volume:
108
Journal issue:
1
Pages contribution:
25-34
Language:
de
Fulltext / DOI:
doi:10.1007/s00113-004-0888-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15526179
Print-ISSN:
0177-5537
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff)
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