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Title:

Effective inhibition of experimental metastasis and prolongation of survival in mice by a potent factor Xa-specific synthetic serine protease inhibitor with weak anticoagulant activity.

Document type:
Journal Article
Author(s):
Banke, IJ; Arlt, MJ; Mueller, MM; Sperl, S; Stemberger, A; Stürzebecher, J; Amirkhosravi, A; Moroder, L; Kruger, A
Abstract:
Clinical and experimental evidence suggests that the blood coagulation system is involved in the dissemination of malignant tumors. Consequently, anticoagulant agents have been tested as metastasis suppressors in experimental models. Recently, we have found a close correlation between factor Xa (FXa)-specificity of a series of synthetic serine protease inhibitors and their anti-metastatic potential in a murine T-cell lymphoma metastasis model. Interference of such inhibitors with blood-coagulati...     »
Journal title abbreviation:
Thromb Haemost
Year:
2005
Journal volume:
94
Journal issue:
5
Pages contribution:
1084-93
Language:
eng
Fulltext / DOI:
doi:10.1160/TH05-05-1084
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16363253
Print-ISSN:
0340-6245
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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