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Title:

Optimization of radiation controlled gene expression by adenoviral vectors in vitro.

Document type:
Journal Article; Article
Author(s):
Anton, M; Gomaa, IE; von Lukowicz, T; Molls, M; Gansbacher, B; Würschmidt, F
Abstract:
The radiation-inducible EGR-1-promoter has been used in different gene therapy approaches in order to enhance and locally restrict therapeutic efficacy. The aim of this study was to reduce nonspecific gene expression in the absence of irradiation (IR) in an adenoviral vector. Rat rhabdomyosarcoma R1H tumor cells were infected with adenoviral vectors expressing either EGFP or HSV-TK under control of the murine EGR-1 promoter/enhancer. Cells were irradiated at 0-6 Gy. Gene expression was determine...     »
Journal title abbreviation:
Cancer Gene Ther
Year:
2005
Journal volume:
12
Journal issue:
7
Pages contribution:
640-6
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.cgt.7700829
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15803145
Print-ISSN:
0929-1903
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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