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Titel:

Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium.

Dokumenttyp:
Journal Article
Autor(en):
Rudolph, C; Schillinger, U; Ortiz, A; Plank, C; Golas, MM; Sander, B; Stark, H; Rosenecker, J
Abstract:
The lung is an important target of gene therapeutic interventions. In contrast to intratracheal instillation, inhalation would be the most practical route of administration in clinical applications. Here we show that aerosolized nanogram quantities of pDNA complexed to PEI (350 ng) yielded transfection levels 15-fold higher than a 140-fold higher dose (50 microg) of the same vector applied directly to the lungs of mice via intratracheal intubation. An important efficacy parameter is the osmolari...     »
Zeitschriftentitel:
Mol Ther
Jahr:
2005
Band / Volume:
12
Heft / Issue:
3
Seitenangaben Beitrag:
493-501
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ymthe.2005.03.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16099412
Print-ISSN:
1525-0016
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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