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Titel:

Methodological optimization of polyethylenimine (PEI)-based gene delivery to the lungs of mice via aerosol application.

Dokumenttyp:
Journal Article
Autor(en):
Rudolph, C; Ortiz, A; Schillinger, U; Jauernig, J; Plank, C; Rosenecker, J
Abstract:
BACKGROUND: Polyethylenimine (PEI) has been successfully used for gene delivery to the lungs of mice via aerosol application using a whole body nebulization device. In this report we optimized the design of such an aerosol device. METHODS: Aerosol devices were constructed as either serial inhalation apparatus or as a whole body nebulization chamber connected to an aerosol spacer placed in a horizontal or vertical position. PEI-based gene vectors were nebulized using a standard jet nebulizer and...     »
Zeitschriftentitel:
J Gene Med
Jahr:
2005
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
59-66
Sprache:
eng
Volltext / DOI:
doi:10.1002/jgm.646
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15538727
Print-ISSN:
1099-498X
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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