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Titel:

Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes.

Dokumenttyp:
Journal Article; Article
Autor(en):
Bölck, B; Munch, G; Mackenstein, P; Hellmich, M; Hirsch, I; Reuter, H; Hattebuhr, N; Weig, HJ; Ungerer, M; Brixius, K; Schwinger, RH
Abstract:
The Na(+)/Ca(2+) exchanger (NCX) may influence cardiac function depending on its predominant mode of action, forward mode or reverse mode, during the contraction-relaxation cycle. The intracellular Na(+) concentration ([Na(+)](i)) and the duration of the action potential as well as the level of NCX protein expression regulate the mode of action of NCX. [Na(+)](i) and NCX expression have been reported to be increased in human heart failure. Nevertheless, the consequences of altered NCX expression...     »
Zeitschriftentitel:
Am J Physiol Heart Circ Physiol
Jahr:
2004
Band / Volume:
287
Heft / Issue:
4
Seitenangaben Beitrag:
H1435-45
Sprache:
eng
Volltext / DOI:
doi:10.1152/ajpheart.00397.2003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15165985
Print-ISSN:
0363-6135
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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