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Titel:

Inducible nonviral gene expression in the treatment of osteochondral defects.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ueblacker, P; Wagner, B; Kruger, A; Vogt, S; DeSantis, G; Kennerknecht, E; Brill, T; Hillemanns, M; Salzmann, GM; Imhoff, AB; Plank, C; Gansbacher, B; Martinek, V
Abstract:
OBJECTIVE: The repair of osteochondral defects with chondrocytes genetically modified to express desired growth factors promises great potential in orthopaedic therapy. Controlled expression of the transgenes is required in many instances. The objective of the present study was to demonstrate the inducibility of tetracycline-responsive transgene expression in osteochondral defects in the knee joint filled with genetically modified chondrocyte implants. METHODS: An expression plasmid containing t...     »
Zeitschriftentitel:
Osteoarthritis Cartilage
Jahr:
2004
Band / Volume:
12
Heft / Issue:
9
Seitenangaben Beitrag:
711-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.joca.2004.05.011
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15325637
Print-ISSN:
1063-4584
TUM Einrichtung:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung
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