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Title:

Inducible nonviral gene expression in the treatment of osteochondral defects.

Document type:
Journal Article; Article
Author(s):
Ueblacker, P; Wagner, B; Kruger, A; Vogt, S; DeSantis, G; Kennerknecht, E; Brill, T; Hillemanns, M; Salzmann, GM; Imhoff, AB; Plank, C; Gansbacher, B; Martinek, V
Abstract:
OBJECTIVE: The repair of osteochondral defects with chondrocytes genetically modified to express desired growth factors promises great potential in orthopaedic therapy. Controlled expression of the transgenes is required in many instances. The objective of the present study was to demonstrate the inducibility of tetracycline-responsive transgene expression in osteochondral defects in the knee joint filled with genetically modified chondrocyte implants. METHODS: An expression plasmid containing t...     »
Journal title abbreviation:
Osteoarthritis Cartilage
Year:
2004
Journal volume:
12
Journal issue:
9
Pages contribution:
711-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.joca.2004.05.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15325637
Print-ISSN:
1063-4584
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung
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