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Title:

Functional evaluation of the apoptosome in renal cell carcinoma.

Document type:
Journal Article; Article
Author(s):
Gerhard, MC; Zantl, N; Weirich, G; Schliep, S; Seiffert, B; Häcker, G
Abstract:
Renal cell carcinoma (RCC) responds very poorly to chemo- or radiotherapy. Renal cell carcinoma cell lines have been described to be resistant to apoptosis-inducing stimuli and to lack caspase expression. Here, we provide a structural and functional assessment of the apoptosome, the central caspase-activating signalling complex and a candidate for apoptosis-inactivating mutations. Cells from RCC cell lines and clinical samples isolated from RCC patients were included. Apoptosome function was mea...     »
Journal title abbreviation:
Br J Cancer
Year:
2003
Journal volume:
89
Journal issue:
11
Pages contribution:
2147-54
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.bjc.6601436
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14647151
Print-ISSN:
0007-0920
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Urologische Klinik und Poliklinik
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