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Title:

Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells.

Document type:
Journal Article; Article
Author(s):
Heit, A; Maurer, T; Hochrein, H; Bauer, S; Huster, KM; Busch, DH; Wagner, H
Abstract:
Covalent linkage of immunostimulatory CpG DNA to OVA results in CpG DNA-aided cross-presentation of OVA by dendritic cells (DCs). In vivo, cross-presentation is conditional for cross-priming of OVA-specific CD8 T cells. In this study, we investigated the involvement of the CpG DNA receptor Toll-like receptor (TLR)9 in CpG DNA-aided cross-presentation and cross-priming. Although CpG DNA-aided cross-presentation is not altered in TLR9-deficient cells, TLR9 is required for maturation of APC allowin...     »
Journal title abbreviation:
J Immunol
Year:
2003
Journal volume:
170
Journal issue:
6
Pages contribution:
2802-5
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12626528
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Urologische Klinik und Poliklinik
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