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Title:

Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors.

Document type:
Journal Article
Author(s):
Banke, IJ; Arlt, MJ; Pennington, C; Kopitz, C; Steinmetzer, T; Schweinitz, A; Gansbacher, B; Quigley, JP; Edwards, DR; Stürzebecher, J; Kruger, A
Abstract:
Although tumors frequently show elevated protease activities, the concept of anti-proteolytic cancer therapy has lost momentum after failure of clinical trials with broad-spectrum matrix metalloproteinase inhibitors. Thus we need to adapt our design strategies for protease inhibitors. Here, we employed a series of seven structurally fine-modulated and pharmacokinetically closely related synthetic 4-amidinobenzylamine-based inhibitors with distinct selectivity for prototypical serine proteases in...     »
Journal title abbreviation:
Biol Chem
Year:
2003
Journal volume:
384
Journal issue:
10-11
Pages contribution:
1515-25
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14669995
Print-ISSN:
1431-6730
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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