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Title:

High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread.

Document type:
Journal Article
Author(s):
Sato, S; Kopitz, C; Schmalix, WA; Muehlenweg, B; Kessler, H; Schmitt, M; Kruger, A; Magdolen, V
Abstract:
Urokinase-type plasminogen activator (uPA) binds with high affinity to its specific cell surface receptor (uPAR) (CD87) via a well-defined sequence within the N-terminal region of uPA (uPA(19-31)). Since this uPA/uPAR-interaction plays a significant role in tumor cell invasion and metastasis, it has become an attractive therapeutic target. Two small peptidic cyclic competitive antagonists of uPA/uPAR-interaction have been developed, based on the uPAR binding site in uPA: WX-360 (cyclo(21,29)[D-C...     »
Journal title abbreviation:
FEBS Lett
Year:
2002
Journal volume:
528
Journal issue:
1-3
Pages contribution:
212-6
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12297307
Print-ISSN:
0014-5793
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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