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Title:

YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Holm, PS; Bergmann, S; Jürchott, K; Lage, H; Brand, K; Ladhoff, A; Mantwill, K; Curiel, DT; Dobbelstein, M; Dietel, M; Gansbacher, B; Royer, HD
Abstract:
The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA replication, and it was thought that targeting of p53 by E1B-55kDa is essential for this process. Here we have identified a previously unrecognized function of E1B for adenovirus replication. We found that E1B-55kDa is involved in targeting the transcription factor YB-1 to the nuclei of adenovirus type 5-infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and...     »
Journal title abbreviation:
J Biol Chem
Year:
2002
Journal volume:
277
Journal issue:
12
Pages contribution:
10427-34
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M106955200
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/11788582
Print-ISSN:
0021-9258
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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