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Title:

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo.

Document type:
Journal Article; Article
Author(s):
Scherer, F; Anton, M; Schillinger, U; Henke, J; Bergemann, C; Kruger, A; Gansbacher, B; Plank, C
Abstract:
Low efficiencies of nonviral gene vectors, the receptor-dependent host tropism of adenoviral or low titers of retroviral vectors limit their utility in gene therapy. To overcome these deficiencies, we associated gene vectors with superparamagnetic nanoparticles and targeted gene delivery by application of a magnetic field. This potentiated the efficacy of any vector up to several hundred-fold, allowed reduction of the duration of gene delivery to minutes, extended the host tropism of adenoviral...     »
Journal title abbreviation:
Gene Ther
Year:
2002
Journal volume:
9
Journal issue:
2
Pages contribution:
102-9
Language:
eng
Fulltext / DOI:
doi:10.1038/sj/gt/3301624
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/11857068
Print-ISSN:
0969-7128
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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