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Titel:

High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread.

Dokumenttyp:
Journal Article
Autor(en):
Sato, S; Kopitz, C; Schmalix, WA; Muehlenweg, B; Kessler, H; Schmitt, M; Kruger, A; Magdolen, V
Abstract:
Urokinase-type plasminogen activator (uPA) binds with high affinity to its specific cell surface receptor (uPAR) (CD87) via a well-defined sequence within the N-terminal region of uPA (uPA(19-31)). Since this uPA/uPAR-interaction plays a significant role in tumor cell invasion and metastasis, it has become an attractive therapeutic target. Two small peptidic cyclic competitive antagonists of uPA/uPAR-interaction have been developed, based on the uPAR binding site in uPA: WX-360 (cyclo(21,29)[D-C...     »
Zeitschriftentitel:
FEBS Lett
Jahr:
2002
Band / Volume:
528
Heft / Issue:
1-3
Seitenangaben Beitrag:
212-6
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12297307
Print-ISSN:
0014-5793
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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