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Titel:

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo.

Dokumenttyp:
Journal Article; Article
Autor(en):
Scherer, F; Anton, M; Schillinger, U; Henke, J; Bergemann, C; Kruger, A; Gansbacher, B; Plank, C
Abstract:
Low efficiencies of nonviral gene vectors, the receptor-dependent host tropism of adenoviral or low titers of retroviral vectors limit their utility in gene therapy. To overcome these deficiencies, we associated gene vectors with superparamagnetic nanoparticles and targeted gene delivery by application of a magnetic field. This potentiated the efficacy of any vector up to several hundred-fold, allowed reduction of the duration of gene delivery to minutes, extended the host tropism of adenoviral...     »
Zeitschriftentitel:
Gene Ther
Jahr:
2002
Band / Volume:
9
Heft / Issue:
2
Seitenangaben Beitrag:
102-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj/gt/3301624
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/11857068
Print-ISSN:
0969-7128
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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