Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.

Dokumenttyp:
Journal Article
Autor(en):
Arlt, M; Kopitz, C; Pennington, C; Watson, KL; Krell, HW; Bode, W; Gansbacher, B; Khokha, R; Edwards, DR; Kruger, A
Abstract:
The recognition that matrix metalloproteinases (MMPs) facilitate tumor cell invasion and metastasis has led to the development of synthetic MMP inhibitors (MMPIs) as cancer therapeutic agents. Because several Phase III trials failed recently to show efficacy of broad-spectrum MMPIs in advanced cancer, the feasibility of MMPs as therapeutic targets has been challenged. However, it has not yet been determined whether MMPIs that have increased specificity may have greater benefit. We show that MMP-...     »
Zeitschriftentitel:
Cancer Res
Jahr:
2002
Band / Volume:
62
Heft / Issue:
19
Seitenangaben Beitrag:
5543-50
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12359766
Print-ISSN:
0008-5472
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
 BibTeX