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Titel:

Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.

Dokumenttyp:
Journal Article; Article
Autor(en):
Bader, BL; Smyth, N; Nedbal, S; Miosge, N; Baranowsky, A; Mokkapati, S; Murshed, M; Nischt, R
Abstract:
Nidogen 1 and 2 are basement membrane glycoproteins, and previous biochemical and functional studies indicate that they may play a crucial role in basement membrane assembly. While they show a divergent expression pattern in certain adult tissues, both have a similar distribution during development. Gene knockout studies in mice demonstrated that the loss of either isoform has no effect on basement membrane formation and organ development, suggesting complementary functions. Here, we show that t...     »
Zeitschriftentitel:
Mol Cell Biol
Jahr:
2005
Band / Volume:
25
Heft / Issue:
15
Seitenangaben Beitrag:
6846-56
Sprache:
eng
Volltext / DOI:
doi:10.1128/MCB.25.15.6846-6856.2005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16024816
Print-ISSN:
0270-7306
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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