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Titel:

Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism.

Dokumenttyp:
Clinical Trial; Journal Article; Randomized Controlled Trial; Article
Autor(en):
Hauner, H; Meier, M; Jöckel, KH; Frey, UH; Siffert, W
Abstract:
BACKGROUND: Sibutramine, a centrally acting noradrenaline and serotonin re-uptake inhibitor, enhances satiety and is frequently used to support weight loss. However, a significant variability exists among individuals concerning the response to sibutramine. METHODS: We genotyped 111 participants of a randomized placebo-controlled clinical trial for the GNB3 C825T polymorphism and analysed associations of genotypes with treatment outcome. Patients undergoing a structured weight loss programme were...     »
Zeitschriftentitel:
Pharmacogenetics
Jahr:
2003
Band / Volume:
13
Heft / Issue:
8
Seitenangaben Beitrag:
453-9
Sprache:
eng
Volltext / DOI:
doi:10.1097/01.fpc.0000054109.14659.b4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12893983
Print-ISSN:
0960-314X
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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