Benutzer: Gast  Login
Weniger Felder
Einfache Suche
Titel:

HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes.

Dokumenttyp:
Journal Article; Article
Autor(en):
van Harmelen, V; Skurk, T; Röhrig, K; Hauner, H
Abstract:
Human adipose tissue is a main contributor to plasma levels of pro-inflammatory cytokine IL-6. How IL-6 expression is regulated in adipocytes remains unclear. In the current study, we investigated the effect of the HMG-CoA reductase inhibitor, cerivastatin, on the production of IL-6 from cultured human adipocytes. Cerivastatin reduced both IL-6 mRNA and secretion in a dose- and time-dependent manner. The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthes...     »
Zeitschriftentitel:
Horm Metab Res
Jahr:
2003
Band / Volume:
35
Heft / Issue:
8
Seitenangaben Beitrag:
466-70
Sprache:
eng
Volltext / DOI:
doi:10.1055/s-2003-41803
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12953163
Print-ISSN:
0018-5043
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
 BibTeX