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Title:

HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes.

Document type:
Journal Article; Article
Author(s):
van Harmelen, V; Skurk, T; Röhrig, K; Hauner, H
Abstract:
Human adipose tissue is a main contributor to plasma levels of pro-inflammatory cytokine IL-6. How IL-6 expression is regulated in adipocytes remains unclear. In the current study, we investigated the effect of the HMG-CoA reductase inhibitor, cerivastatin, on the production of IL-6 from cultured human adipocytes. Cerivastatin reduced both IL-6 mRNA and secretion in a dose- and time-dependent manner. The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthes...     »
Journal title abbreviation:
Horm Metab Res
Year:
2003
Journal volume:
35
Journal issue:
8
Pages contribution:
466-70
Language:
eng
Fulltext / DOI:
doi:10.1055/s-2003-41803
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12953163
Print-ISSN:
0018-5043
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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