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Title:

An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE.

Document type:
Journal Article; Article
Author(s):
Hecker, J; Diethers, A; Schulz, D; Sabri, A; Plum, M; Michel, Y; Mempel, M; Ollert, M; Jakob, T; Blank, S; Braren, I; Spillner, E
Abstract:
Analyses of the molecular basis underlying allergenicity and allergen cross-reactivity, as well as improvement of allergy diagnostics and therapeutics, are hampered by the lack of human monoclonal IgE antibodies and knowledge about their epitopes. Here, we addressed the consecutive generation and epitope delineation of a human monoclonal IgE against the prototypic allergen Bet v 1.Phage-display scFv hybrid libraries of allergic donor-derived VH epsilon and synthetic VL were established from 107...     »
Journal title abbreviation:
Allergy
Year:
2012
Journal volume:
67
Journal issue:
12
Pages contribution:
1530-7
Language:
eng
Fulltext / DOI:
doi:10.1111/all.12045
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23066955
Print-ISSN:
0105-4538
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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