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Titel:

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.

Dokumenttyp:
Journal Article
Autor(en):
Paternoster, L; Standl, M; Chen, CM; Ramasamy, A; Bønnelykke, K; Duijts, L; Ferreira, MA; Alves, AC; Thyssen, JP; Albrecht, E; Baurecht, H; Feenstra, B; Sleiman, PM; Hysi, P; Warrington, NM; Curjuric, I; Myhre, R; Curtin, JA; Groen-Blokhuis, MM; Kerkhof, M; Sääf, A; Franke, A; Ellinghaus, D; Folster-Holst, R; Dermitzakis, E; Montgomery, SB; Prokisch, H; Heim, K; Hartikainen, AL; Pouta, A; Pekkanen, J; Blakemore, AI; Buxton, JL; Kaakinen, M; Duffy, DL; Madden, PA; Heath, AC; Montgomery, GW; Thomp...     »
Abstract:
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-w...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2012
Band / Volume:
44
Heft / Issue:
2
Seitenangaben Beitrag:
187-92
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.1017
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22197932
Print-ISSN:
1061-4036
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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