Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.

Paternoster, L; Standl, M; Chen, CM; Ramasamy, A; Bønnelykke, K; Duijts, L; Ferreira, MA; Alves, AC; Thyssen, JP; Albrecht, E; Baurecht, H; Feenstra, B; Sleiman, PM; Hysi, P; Warrington, NM; Curjuric, I; Myhre, R; Curtin, JA; Groen-Blokhuis, MM; Kerkhof, M; Sääf, A; Franke, A; Ellinghaus, D; Folster-Holst, R; Dermitzakis, E; Montgomery, SB; Prokisch, H; Heim, K; Hartikainen, AL; Pouta, A; Pekkanen, J; Blakemore, AI; Buxton, JL; Kaakinen, M; Duffy, DL; Madden, PA; Heath, AC; Montgomery, GW; Thompson, PJ; Matheson, MC; Le Souëf, P; St Pourcain, B; Smith, GD; Henderson, J; Kemp, JP; Timpson, NJ; Deloukas, P; Ring, SM; Wichmann, HE; Müller-Nurasyid, M; Novak, N; Klopp, N; Rodriguez, E; McArdle, W; Linneberg, A; Menné, T; Nohr, EA; Hofman, A; Uitterlinden, AG; van Duijn, CM; Rivadeneira, F; de Jongste, JC; van der Valk, RJ; Wjst, M; Jogi, R; Geller, F; Boyd, HA; Murray, JC; Kim, C; Mentch, F; March, M; Mangino, M; Spector, TD; Bataille, V; Pennell, CE; Holt, PG; Sly, P; Tiesler, CM; Thiering, E; Illig, T; Imboden, M; Nystad, W; Simpson, A; Hottenga, JJ; Postma, D; Koppelman, GH; Smit, HA; Söderhäll, C; Chawes, B; Kreiner-Møller, E; Bisgaard, H; Melén, E; Boomsma, DI; Custovic, A; Jacobsson, B; Probst-Hensch, NM; Palmer, LJ; Glass, D; Hakonarson, H; Melbye, M; Jarvis, DL; Jaddoe, VW; Gieger, C; Strachan, DP; Martin, NG; Jarvelin, MR; Heinrich, J; Evans, DM; Weidinger, S     «

Paternoster, L; Standl, M; Chen, CM; Ramasamy, A; Bønnelykke, K; Duijts, L; Ferreira, MA; Alves, AC; Thyssen, JP; Albrecht, E; Baurecht, H; Feenstra, B; Sleiman, PM; Hysi, P; Warrington, NM; Curjuric, I; Myhre, R; Curtin, JA; Groen-Blokhuis, MM; Kerkhof, M; Sääf, A; Franke, A; Ellinghaus, D; Folster-Holst, R; Dermitzakis, E; Montgomery, SB; Prokisch, H; Heim, K; Hartikainen, AL; Pouta, A; Pekkanen, J; Blakemore, AI; Buxton, JL; Kaakinen, M; Duffy, DL; Madden, PA; Heath, AC; Montgomery, GW; Thomp...     »

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10(-13)) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 × 10(-9)), both of which are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 × 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.     «

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-w...     »