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Title:

A comprehensive analysis of the COL29A1 gene does not support a role in eczema.

Document type:
Journal Article; Article
Author(s):
Naumann, A; Söderhäll, C; Folster-Holst, R; Baurecht, H; Harde, V; Müller-Wehling, K; Rodriguez, E; Ruether, A; Franke, A; Wagenpfeil, S; Novak, N; Mempel, M; Kalali, BN; Allgaeuer, M; Koch, J; Gerhard, M; Melén, E; Wahlgren, CF; Kull, I; Stahl, C; Pershagen, G; Lauener, R; Riedler, J; Doekes, G; Scheynius, A; Illig, T; von Mutius, E; Schreiber, S; Kere, J; Kabesch, M; Weidinger, S
Abstract:
Based on a recent positional cloning approach, it was claimed that the collagen 29A1 gene (COL29A1), which encodes an epidermal collagen, represents a major risk gene for eczema underlying a previously reported linkage to chromosome 3q21. However, thus far, not a single replication attempt has been published, and no definitive functional data have been provided.We aimed to determine whether COL29A1 polymorphisms contribute to eczema susceptibility and whether COL29A1 expression is altered in ecz...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2011
Journal volume:
127
Journal issue:
5
Pages contribution:
1187-94.e7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2010.12.1123
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21353297
Print-ISSN:
0091-6749
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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