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Title:

CD28 costimulation regulates FOXP3 in a RelA/NF-?B-dependent mechanism.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Soligo, M; Camperio, C; Caristi, S; Scottà, C; Del Porto, P; Costanzo, A; Mantel, PY; Schmidt-Weber, CB; Piccolella, E
Abstract:
The molecular mechanisms whereby CD28 alone or associated with TCR can regulate FOXP3 expression are not understood, although the importance of CD28 as a pivotal regulator of CD4(+) CD25(+) FOXP3(+) T cells is well recognized. We previously demonstrated that unique CD28-induced, NF-?B-dependent signals were sufficient to activate FOXP3 transcription in human CD4(+) CD25(-) T cells; however, the exact mechanisms are currently unknown. In this study, we have identified novel ?B-binding sites on F...     »
Journal title abbreviation:
Eur J Immunol
Year:
2011
Journal volume:
41
Journal issue:
2
Pages contribution:
503-13
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.201040712
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21268019
Print-ISSN:
0014-2980
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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