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Title:

Immunosuppression affects CD4+ mRNA expression and induces Th2 dominance in the microenvironment of cutaneous squamous cell carcinoma in organ transplant recipients.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kosmidis, M; Dziunycz, P; Suárez-Fariñas, M; Mühleisen, B; Schärer, L; Läuchli, S; Hafner, J; French, LE; Schmidt-Weber, C; Carucci, JA; Hofbauer, GF
Abstract:
Squamous cell carcinoma (SCC) is the most frequent cancer in organ transplant recipients (OTRs). The immune system plays a major role in the fight against SCC, however, little is known about the local inflammatory response in SCC at all. We analyzed quantity and quality of the perineoplastic inflammatory SCC microenvironment in immunocompetent patients and immmunosuppressed OTRs. RNA expression profile of SCC patients was analyzed for 8 different sets of genes relating to Th1 versus Th2 response...     »
Journal title abbreviation:
J Immunother
Year:
2010
Journal volume:
33
Journal issue:
5
Pages contribution:
538-46
Language:
eng
Fulltext / DOI:
doi:10.1097/CJI.0b013e3181cc2615
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20463594
Print-ISSN:
1524-9557
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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