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Title:

Effects of ultrafine particles-induced oxidative stress on Clara cells in allergic lung inflammation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Alessandrini, F; Weichenmeier, I; van Miert, E; Takenaka, S; Karg, E; Blume, C; Mempel, M; Schulz, H; Bernard, A; Behrendt, H
Abstract:
Clara cell protein (CC16), the main secretory product of bronchiolar Clara cells, plays an important protective role in the respiratory tract against oxidative stress and inflammation. The purpose of the study was to investigate the role of elemental carbon ultrafine particles (EC-UFP)-induced oxidative stress on Clara cells and CC16 in a mouse model of allergic lung inflammation.Ovalbumin (OVA)-sensitized mice were exposed to EC-UFP (507 microg/m(3) for 24 h) or filtered air immediately prior t...     »
Journal title abbreviation:
Part Fibre Toxicol
Year:
2010
Journal volume:
7
Pages contribution:
11
Language:
eng
Fulltext / DOI:
doi:10.1186/1743-8977-7-11
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20420656
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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