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Title:

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

Document type:
Journal Article
Author(s):
Lauterbach, H; Bathke, B; Gilles, S; Traidl-Hoffmann, C; Luber, CA; Fejer, G; Freudenberg, MA; Davey, GM; Vremec, D; Kallies, A; Wu, L; Shortman, K; Chaplin, P; Suter, M; O'Keeffe, M; Hochrein, H
Abstract:
Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-?s (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection in vivo induces large amounts of IFN-?, which depended on hematopoietic cells and the presence of TLR3 (Toll-like receptor 3), IRF3 (IFN regulatory factor 3), IRF7, IFN-I receptor, Fms-related tyrosine kinase 3 ligand (FL), and IRF8 but not on MyD88 (myeloid differentiation fact...     »
Journal title abbreviation:
J Exp Med
Year:
2010
Journal volume:
207
Journal issue:
12
Pages contribution:
2703-17
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20092720
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20975040
Print-ISSN:
0022-1007
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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