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Title:

Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation.

Document type:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Author(s):
Gutermuth, J; Nograles, KE; Miyagawa, F; Nelson, E; Cho, YH; Katz, SI
Abstract:
Although the pathogenic role of B cells and CD4 T cells has been studied extensively, less is known about the role of CD8 T cells in autoimmunity and self-tolerance. To evaluate the role of CD8 T cells in autoimmunity and its modulation using self-peptides, we used mice expressing soluble OVA (sOVA) under control of the keratin-14 promoter. Spontaneous autoimmunity occurred when sOVA mice were crossed with OT-I mice, whose CD8 T cells carry a Valpha2/Vbeta5-transgenic TCR with specificity for th...     »
Journal title abbreviation:
J Immunol
Year:
2009
Journal volume:
183
Journal issue:
5
Pages contribution:
3130-8
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.0900793
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19675167
Print-ISSN:
0022-1767
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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