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Titel:

Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Broere, F; du Pré, MF; van Berkel, LA; Garssen, J; Schmidt-Weber, CB; Lambrecht, BN; Hendriks, RW; Nieuwenhuis, EE; Kraal, G; Samsom, JN
Abstract:
Oral intake of protein leads to tolerance through the induction of regulatory T cells (Tr cells) in mesenteric lymph nodes (MLNs). Here we show that the inhibition of cyclooxygenase-2 (COX-2) in vivo suppressed oral tolerance and was associated with enhanced differentiation of interleukin (IL)-4-producing T cells and reduced Foxp3(+) Tr-cell differentiation in MLN. As a result, the functional suppressive capacity of these differentiated mucosal T cells was lost. IL-4 was causally related to loss...     »
Zeitschriftentitel:
Mucosal Immunol
Jahr:
2009
Band / Volume:
2
Heft / Issue:
3
Seitenangaben Beitrag:
254-64
Sprache:
eng
Volltext / DOI:
doi:10.1038/mi.2009.2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19262503
Print-ISSN:
1933-0219
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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