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Titel:

Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Siegmund, K; Rückert, B; Ouaked, N; Burgler, S; Speiser, A; Akdis, CA; Schmidt-Weber, CB
Abstract:
Forkhead box p3 (FOXP3) is known to program the acquisition of suppressive capacities in CD4(+) regulatory T cells (Treg), whereas its role in CD8(+) T cells is unknown. The current study investigates whether FOXP3 also acts as a Treg master switch in peripheral blood and tonsillar CD8(+) T cells. Single-cell analyses reveal the existence of a FOXP3(+)CD8(+) population in human tonsils, whereas FOXP3(+)CD8(+) T cells are rarely detected in peripheral blood. Tonsillar FOXP3(+)CD8(+) T cells exhib...     »
Zeitschriftentitel:
J Immunol
Jahr:
2009
Band / Volume:
182
Heft / Issue:
4
Seitenangaben Beitrag:
2124-30
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.0802271
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19201865
Print-ISSN:
0022-1767
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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