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Titel:

Year-to-year variation in release of Bet v 1 allergen from birch pollen: evidence for geographical differences between West and South Germany.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Buters, JT; Kasche, A; Weichenmeier, I; Schober, W; Klaus, S; Traidl-Hoffmann, C; Menzel, A; Huss-Marp, J; Kramer, U; Behrendt, H
Abstract:
BACKGROUND: The release of the aeroallergen Bet v 1 from pollen is a major determinant in the etiology of allergic airway disease due to birch pollen. OBJECTIVE: We determined the release of the major birch pollen allergen Bet v 1 from pollen of birch trees growing in 2 different geographic regions in Germany for 2 consecutive years. METHODS: Catkins were collected during pollination in 2002 and 2003 from 82 healthy trees in South (Munich) and West Germany (North Rhine-Westphalia). The release of Bet v 1 from pollen samples was determined by a Bet v 1-specific ELISA. RESULTS: Pollen from South Germany released about 3 times more Bet v 1 than those from West Germany in both 2002 and 2003 (p = 0.034 and p = 0.007, respectively). This was independent of the number of pollen during the pollen flight season. In 2003, the release of Bet v 1 from pollen was more than 5 times higher than in 2002 in both regions (South Germany 6.1 times, p < 0.001; West Germany 5.4 times, p = 0.003). CONCLUSIONS: Despite large individual differences, there seem to be regional and year-to-year variations in Bet v 1 release from birch pollen. Therefore, the combination of pollen count and release of Bet v 1 from this pollen must be assessed to estimate Bet v 1 exposure reliably.
Zeitschriftentitel:
Int Arch Allergy Immunol
Jahr:
2008
Band / Volume:
145
Heft / Issue:
2
Seitenangaben Beitrag:
122-30
Sprache:
eng
Volltext / DOI:
doi:10.1159/000108137
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17848805
Print-ISSN:
1018-2438
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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