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Title:

Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model.

Document type:
Journal Article; Article
Author(s):
Scherf, W; Burdach, S; Hansen, G
Abstract:
Allergic asthma is characterized by airway hyperreactivity (AHR), eosinophilic airway inflammation and elevated serum IgE levels. T-helper 2 (Th2) cells play a critical role in the pathogenesis of asthma, but the immunological mechanisms that inhibit Th2 cell function in vivo are not well understood. Conflicting results regarding the protective role of Th1 cytokines and TGF-beta in asthma have been reported. To further investigate the role of TGF-beta(1 )in asthma, we examined mice heterozygous...     »
Journal title abbreviation:
Eur J Immunol
Year:
2005
Journal volume:
35
Journal issue:
1
Pages contribution:
198-206
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200425209
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15593298
Print-ISSN:
0014-2980
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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