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Title:

CpG island methylation and expression of tumour-associated genes in lung carcinoma.

Document type:
Journal Article; Article
Author(s):
Dammann, R; Strunnikova, M; Schagdarsurengin, U; Rastetter, M; Papritz, M; Hattenhorst, UE; Hofmann, HS; Silber, RE; Burdach, S; Hansen, G
Abstract:
In this study, microarray analysis was used to identify tumour-related genes that were down regulated in lung carcinoma. The promoter sequences of the identified genes were analysed for methylation patterns. In lung cancer cell lines, CpG island methylation was frequently detected for TIMP4 (64%), SOX18 (73%), EGF-like domain 7 (56%), CD105 (71%), SEMA2 (55%), RASSF1A (71%), p16 (56%) SLIT2 (100%) and TIMP3 (29%). Methylation was however rarely observed in cell lines for SLIT3 (18%) and DLC1 (18...     »
Journal title abbreviation:
Eur J Cancer
Year:
2005
Journal volume:
41
Journal issue:
8
Pages contribution:
1223-36
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ejca.2005.02.020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15911247
Print-ISSN:
0959-8049
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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