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Titel:

Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model.

Dokumenttyp:
Journal Article; Article
Autor(en):
Scherf, W; Burdach, S; Hansen, G
Abstract:
Allergic asthma is characterized by airway hyperreactivity (AHR), eosinophilic airway inflammation and elevated serum IgE levels. T-helper 2 (Th2) cells play a critical role in the pathogenesis of asthma, but the immunological mechanisms that inhibit Th2 cell function in vivo are not well understood. Conflicting results regarding the protective role of Th1 cytokines and TGF-beta in asthma have been reported. To further investigate the role of TGF-beta(1 )in asthma, we examined mice heterozygous...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2005
Band / Volume:
35
Heft / Issue:
1
Seitenangaben Beitrag:
198-206
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.200425209
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15593298
Print-ISSN:
0014-2980
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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