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Titel:

Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents.

Dokumenttyp:
Journal Article; Article
Autor(en):
Henriksen, G; Platzer, S; Marton, J; Hauser, A; Berthele, A; Schwaiger, M; Marinelli, L; Lavecchia, A; Novellino, E; Wester, HJ
Abstract:
The synthesis, evaluation, and molecular modeling of a series of 18F-labeled 4-anilidopiperidines with high affinities for the mu-opioid receptor (mu-OR) are reported. On the basis of the high brain uptake and selective retention in brain regions that contain a high concentration of the mu-OR, combined with a good metabolic stability, [18F]fluoro-pentyl carfentanil ([18F]4) and 2-(+/-)[18F]fluoropropyl-sufentanil ([18F]6) were selected as the lead compounds for further evaluation. The binding af...     »
Zeitschriftentitel:
J Med Chem
Jahr:
2005
Band / Volume:
48
Heft / Issue:
24
Seitenangaben Beitrag:
7720-32
Sprache:
eng
Volltext / DOI:
doi:10.1021/jm0507274
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16302812
Print-ISSN:
0022-2623
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
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