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Titel:

COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression.

Dokumenttyp:
Journal Article; Article
Autor(en):
Berthele, A; Platzer, S; Jochim, B; Boecker, H; Buettner, A; Conrad, B; Riemenschneider, M; Toelle, TR
Abstract:
Recent data from [(11)C]carfentanil ligand-PET indicate that in the human brain, the availability of mu-opioid (MOP) receptor binding sites is affected by the Val(108/158)Met polymorphism of the catechol-O-methyltransferase (COMT) gene. This prompted us to validate the impact of COMT Val(108/158)Met on MOP receptors in human post-mortem brain. [(3)H]DAMGO receptor autoradiography was performed in frontal cortex, basal ganglia, thalamus and cerebellum (8 Met/Met, 6 Met/Val, 3 Val/Val). With respe...     »
Zeitschriftentitel:
Neuroimage
Jahr:
2005
Band / Volume:
28
Heft / Issue:
1
Seitenangaben Beitrag:
185-93
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.neuroimage.2005.05.030
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16040257
Print-ISSN:
1053-8119
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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