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Title:

Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Hoffmann, TK; Trellakis, S; Okulicz, K; Schüler, P; Greve, J; Arnolds, J; Bergmann, C; Bas, M; Lang, S; Lehnerdt, G; Brandau, S; Mattheis, S; Scheckenbach, K; Finn, OJ; Whiteside, TL; Sonkoly, E
Abstract:
The cyclin B1/CDC2 complex governs entry into mitosis by regulating the G(2)/M checkpoint, and it can be repressed by the tumor suppressor p53. We aimed to determine cyclin B1 expression in squamous cell carcinomas of the head and neck (SCCHN) and correlate it with p53 status and clinicopathological parameters.Cyclin B1 and p53 protein expression was analyzed by immunohistochemistry, and p53 mutation analyses were performed.Cytoplasmic expression of cyclin B1 was found in all 26 SCCHN studied. I...     »
Journal title abbreviation:
Anticancer Res
Year:
2011
Journal volume:
31
Journal issue:
10
Pages contribution:
3151-7
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21965721
Print-ISSN:
0250-7005
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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